Tenby was the fifth busiest RNLI lifeboat station in Wales in 2007, new figures show.
The station had 34 inshore lifeboat launches and 15 launches for the all-weather lifeboat.
Wales' most active lifeboat station was Rhyl, which had 115 launches and rescued 65 people.
The crew also spent the longest time at sea, clocking up 113 hours afloat.
Just a few hours behind was Angle, where fundraising is ongoing for a new Tamar class lifeboat.
There, the volunteer crew spent almost 110 hours at sea on rescue operations.
Of the 31 RNLI lifeboat stations in Wales, 12 saw rescue figures rise, including Cardigan, where its 2007 launches were up 24% to 51.
The RNLI says most of its launches last year were to power pleasure craft, with 285 call-outs to vessels in difficulty.
Machinery failure remains the biggest cause of rescue in Wales, and the charity is encouraging people to ensure they are well-equipped and take heed of the RNLI's sea safety advice before taking to the water.
Nationally, the RNLI experienced one of its busiest years on record, with 8,052 launches for its 233 lifeboat stations around the coasts of the UK and Ireland.
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